Senior Computational and Experimental Scientist
Clera · New York, New York
Posted Oct 7, 2026 · Verified open Oct 9, 2026
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ABOUT THE ROLE
Join a lean team at an early-stage AI-driven biotech company, working across computational protein design, experimental biology, and scientific software. You will help close the design-make-test-model loop, using experimental results to improve models and deliver more useful sequences.
WHAT YOU'LL DO
- Refine discrete diffusion, protein language, and structure prediction models, including model architectures and constrained redesign workflows.
- Operate and improve a scientific inference platform, and analyze user behavior, usage patterns, and churn.
- Write, debug, and deploy protocols for liquid-handling robots and manage screening instrumentation.
- Run BLI or SPR assays end-to-end, from assay design and sample preparation through kinetic fitting and quality control.
- Diagnose experimental and computational failure modes, including mass transport, nonspecific binding, aggregation, and poor referencing.
- Design sequences, synthesize or express them, measure kinetics, update models, and iterate on improved candidates.
- Support scientific users and customer adoption with accurate, personalized outreach and an understanding of biotech buying processes.
WHAT WE'RE LOOKING FOR
- At least 2 years building or operating protein design, protein language, or structure prediction systems in a design-make-test workflow.
- At least 3 years in biotech or life sciences software go-to-market, solutions engineering, or customer success, including converting free users to paid offerings.
- Hands-on experience writing production methods for Hamilton, Tecan, Opentrons, or equivalent liquid handlers.
- Hands-on experience designing BLI or SPR assays, fitting kinetic curves, and troubleshooting assay results.
- Practical experience with tools such as ESM, ProtT5, RFdiffusion, BindCraft, or equivalents, plus Python or similar scripting for automation and data analysis.
- Biology, biochemistry, or life sciences knowledge, including protein structure, receptor biology, and scoring functions.
- Experience with scientific software users, biotech sales cycles, peptide design, protein engineering, or drug discovery is valuable.
COMPENSATION & BENEFITS
Consulting engagement compensation is $3,000 to $5,000 per month. Full-time conversion offers a base salary of $80,000 to $200,000 annually, depending on experience, plus equity. Visa sponsorship is not available.
LOCATION
Hybrid, based in New York, United States, with increased on-site presence as internal screening operations launch.